Here is another major spoiler from TVGuide.com about Dexter & Debra relationship in the upcoming season. Check the Q & A below

Q:- Seriously, how did Debra never figure out her brother was a serial killer on Dexter? — Dick
NATALIE: That fact won’t be lost on Deb. In fact, it won’t be long before you hear her say the words: “I am the worst f—ing detective in the world.” Once she understands the scope of her brother’s wrath, their confrontation will include violence and a chase that ends in a puddle of something.
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Dexter has always been one of Deb’s biggest confidents, so it’s not surprising she never suspected him of being a killer. It’s been stated that this season she will be thinking back to all of the instances she should have picked up on the clues. But a co-worker at DISH and I agree that she likely overlooked these details due to the fact that he was her brother. This is part of the reason I am convinced she won’t turn him in, but I can’t wait to find out for sure when I watch the season on my Hopper. With my train ride coinciding with this and many other premieres, I couldn’t be more grateful for the 2,000 hours of recording space. I can’t wait to see the journey Deb takes to discovering the “Dark Passenger.” I hope that she finds a way to deal with Dexter, that will be a difficult struggle considering everything she knew was a lie.